Bioactive Properties – ACTIVA

Apatite formation is the essential requirement of bioactive materials. ACTIVA stimulates mineral apatite formation and the natural remineralization process that knits the restoration and the tooth together and seals margins against microleakage, secondary caries, and failure.

ACTIVA responds to pH cycles and plays an active role in maintaining oral health with release and recharge of significant amounts of calcium, phosphate and fluoride. These mineral components stimulate formation of a protective/connective apatite layer and a natural bonded-seal at the material-tooth interface.

SEM Analysis of ACTIVA BioACTIVE-CEMENT after 21 Days in Saline
Compared to the no saline control, scanning electron microscope (SEM) imaging and energy-dispersive X-ray spectroscopy (EDS) after 21 days in saline shows significant increase in calcium and phosphorus ion concentrations, and decrease in carbon and silica ions, indicating that mineral apatite deposits are forming on the surface.

SEM and EDS Analysis Verifies Bioactive Component
Scanning electron microscope (SEM) imaging and energy-dispersive X-ray spectroscopy (EDS) analysis of dentin discs treated with ACTIVA BioACTIVE-CEMENT and placed in phosphate buffered solution verifies the bioactive component of the material and demonstrates excellent dentinal tubule penetration. A layer of apatite formed and fused the dentin to ACTIVA. (The gap was produced when the specimen was fractured to make the SEM.)

ACTIVA releases and recharges with fluoride, providing long-term patient benefits for improved oral health care.

University testing using fluoride ion concentration gradient diffusion methodology shows the pattern of release and recharge of ACTIVA, Ketac Nano and Triage. The study concludes that “at the seven time points tested, the new bioactive material [ACTIVA] has statistically greater fluoride release after recharge at 24 hours, 1 week and 3 weeks than the other groups tested.”

ACTIVA is a “smart” material that responds to pH cycles in the mouth. During low pH demineralization cycles, ACTIVA releases more phosphate. The phosphate ions can reside in the pellicle layer or saliva and are available to interact with calcium and fluoride ions during higher pH cycles.

ACTIVA BioACTIVE-RESTORATIVE, when tested in vitro for microleakage without a bonding agent, compares favorably with leading composites tested with a bonding agent (Scotchbond Universal Adhesive, 3M ESPE).

ACTIVA BioACTIVE-RESTORATIVE outperforms a leading RMGI when tested for bacterial microleakage in vitro after 2,000 thermocycles.

ACTIVA BioACTIVE-BASE/LINER compares favorably with a leading resin modified glass ionomer material when tested for bacterial microleakage in vitro after 2,000 thermocycles.